Re: Low IgM antibody levels - any cause for concern? Your healthcare provider will order a blood test that measures immunoglobulin levels to diagnose IgG deficiency. 270. However, a reasonable normal range is 45-250mg/dl. Causes Selective IgA deficiency can be inherited or occur spontaneously (due to infections, medication, or unknown causes) [ 44 ]. On the contrary, there are evidences that IgM levels may appear decreased in autoimmune pancreatitis and, furthermore, low IgM concentration may play role in the development of this disorder. However, you have had health problems since childhood. For many years they worked very well and symptoms were greatly reduced. I have very low levels of IgG and was diagnosed with Common Variable Immune Disorder (CVID). However, you have had health problems since childhood. It’s possible to have a normal level of total IgG, so it's important that your provider test the IgG subclasses Monoclonal elevations of IgM occur in macroglobulinemia. IgM deficiency cannot be caused by the pancreatic diabetes. [] Recent series report IgM levels of 29.7±8.7 mg/dL … Low levels of IgM occur in multiple myeloma and some types of leukemia. Unfortunately, for the past two years, my symptoms have increased. Low IgA can be caused by selective IgA deficiency, when only IgA levels are low but other antibodies (IgG, IgM, IgD, and IgE) are normal . Recent studies found an association between low serum IgE levels and the levels of one or more classes of immunoglobulins (i.e. [] Reported IgM concentrations in SIgM deficiency vary from 40 mg/dL (though some sources say 20 mg/dL) to undetectable levels (reference range 45-150 mg/dL in adults). Diagnosis and Tests. IGM : The gamma globulin band as seen in conventional serum protein electrophoresis consists of 5 immunoglobulins. (A) Subjects with a low IgM were more likely to fail to respond to standard treatment. Isolated primary immunoglobulin M deficiency is a poorly defined dysgammaglobulinemia characterized by decreased levels of IgM while levels of other immunoglobulins are normal. Low levels of immunoglobulins mean your immune system isn't working as well as it should. In normal serum, about 5% is immunoglobulin M (IgM). (B) Subjects with a low IgM had a trend toward decreased response to splenectomy. (C) There was no difference in frequency of major bleed based on IgM level. (D) Subjects with low IgM had a lower median platelet count than subjects with a normal IgM. There is … : Good morning, low levels of igm by itself may not be significant. This can affect breathing. I have been receiving IgG infusions for about 10 years now. by pinball on Thu Dec 04, 2014 8:37 am I'm IgG kappa smoldering myeloma - though my IgG is within range near 1,100 with an M-spike that ranges near 0.700 - 0.800 g/dL , normal IgA of aprox. In some people, infections cause scarring that harms the airways and how the lungs work. The 'low', 'normal' and 'high' ranges vary with age, and are also lab-specific. This can be caused by: Medicines that weaken your immune system, such as steroids Selective immunoglobulin M (SIgM) deficiency is a rare form of dysgammaglobulinemia characterized by an isolated low level of serum immunoglobulin M (IgM). IgG, IgA and/or IgM) below the reference range for age 10, 11. Elevations of IgM may be due to polyclonal immunoglobulin production. Causes and Development. The diagnosis is established when blood tests demonstrate undetectable levels of IgA (reported usually as < 5-7 mg/dL), with normal levels of the other major classes of immunoglobulins (IgG and IgM). Occasionally, some patients with IgA deficiency may also have low levels of IgG2 and/or IgG4 and associated antibody deficiency.
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